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This unique cellular function is a critical factor in the outcome of not onlyautoimmune disorders such as intestinal colitis, but also anti-tumor T cell immunity. A critic is“one who forms and expresses judgments of the merits, faults, value, or truth of a matter,”and the word critical is used, here and throughout, to mean “characterized by careful,exact evaluation and judgment” (“Critic/Critical,” 2000)

A critic is“one who forms and expresses judgments of the merits, faults, value, or truth of a matter,”and the word critical is used, here and throughout, to mean “characterized by careful,exact evaluation and judgment” (“Critic/Critical,” 2000). Peripheral immune activation and infl amma-tion occurring in response to systemic infection can leadto alterations in the brain microenvironment that impairCNS function

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